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Impairment of driving skills with a resultant increased risk of road traffic accidents is probably the most important adverse effect.
This side-effect is not unique to flunitrazepam but also occurs with other hypnotic drugs.
Partial, but incomplete tolerance develops to these impairments.A 1989 journal on Clinical Pharmacology reports that benzodiazepines accounted for 52% of prescription forgeries, suggesting that benzodiazepines was a major prescription drug class of abuse.Nitrazepam accounted for 13% of forged prescriptions.Rebound insomnia, worse than baseline insomnia, typically occurs after discontinuation of flunitrazepam even after short-term single nightly dose therapy.Flunitrazepam produces a decrease in delta wave activity.
The presence of 7-aminoflunitrazepam, a pharmacologically-active metabolite and in vitro degradation product, is useful for confirmation of flunitrazepam ingestion.